| Theme |
New Development in CAPD Therapy |
| Title |
Standardization of peritoneal biopsies for CAPD patients |
| Author |
Kazuho Honda |
Department of Pathology, Tokyo Women's Medical University |
| Author |
Hideaki Oda |
Department of Pathology, Tokyo Women's Medical University |
| [ Summary ] |
The main purposes of peritoneal biopsies for CAPD patients are (1) evaluation of peritoneal sclerosis and (2) diagnosis and predictions of EPS. The following aspects should be considered to standardize peritoneal biopsies ; (1) sampling and processing methods for peritoneal tissue specimens, (2) the histological items that should be evaluated and their grading criteria, and (3) the common diagnostic categories for the peritoneal sclerosis. Peritoneal biopsies should be routinely performed during laparoscopy and catheter insertion. The main items for histological evaluation are interstitial fibrosis, vasculopathy and inflammatory states, all of which may be semi-quantitatively graded. The diagnostic categories are determined according to the extent of peritoneal fibrosis. They consist of a normal peritoneum, simple fibrosis, peritoneal sclerosis in the early stage (grade 1), peritoneal sclerosis in the middle stage (grade 2) and peritoneal sclerosis in the advanced stage (grade 3). |