| [ Summary ] |
The carbonyl types of glucose react non-enzymatically with the amino groups of proteins to form advanced glycation end products (AGEs), which are barmful to the peritoneum. Glucose has a lower molecular weight, so that it is rapidly absorbed into the body and ultrafiltration cannot be maintained through out the period.
Peritoneal dialysates, using saccharides, lacking a carbonyl group, such as lactobionate, maltitol and nistose, have equivalent or lower cytotoxity, less glucose degradation products (GDPs), and less reactivity to forms of AGEs compared to glucose. In animal experiments, these dialysates revealed greater ultrafiltration and no differences in dialysate/plasma (D/P) urea. It was therefore determined that there was a possibility of these saccharides being used as new osmotic agents. |