臨牀透析 Vol.18 No.8(2-3-4)


特集名 薬物・毒物中毒と血液浄化法(症例集)
題名 [中毒症例]III. 医薬品 (4) ジギタリス
発刊年月 2002年 07月
著者 田中 敬雄 大阪府済生会中津病院腎臓内科
著者 桑原 隆 大阪府済生会中津病院腎臓内科
【 要旨 】 食思不振を主訴として,77歳の男性が入院した.男性は慢性心不全,慢性腎不全にてジゴキシンを0.25mg/day投与されていた.視力障害などの臨床症状やST部分の盆状低下といった心電図所見よりジギタリス中毒を疑った.ジゴキシンの血中濃度を測定したところ13.80ng/mlと著明な高値を認めたため,ジギタリス中毒と診断した.同日より直接血液灌流(direct hemoperfusion;DHP)を開始した.DHPはダイアライザーとしてHemocels HC-200を用い,血流量100ml/min,1回約2時間施行し,計3回行った.全身状態は徐々に回復し,第60病日に退院した.DHPは比較的,安全に施行でき,ジギタリス中毒に有効な治療法である.
Theme Intoxication of Drugs and Poisons and Blood Purification Therapy (Case Report)
Title Digitalis intoxication
Author Atsuo Tanaka Department of Nephrology, Osaka Saiseikai Nakatsu Hospital
Author Takashi Kuwahara Department of Nephrology, Osaka Saiseikai Nakatsu Hospital
[ Summary ] A 77-year-old male who complained of appetite loss was admitted. Digoxin 0.25mg/day had been administered for chronic heart failure. He was suspected to have digitalis intoxication since he complained of visual disturbances and an electrocardiogram showed abnormal ST depression. Laboratory data demonstrated serum digoxin concentrations of 13.80ng/ml (normal range 0.8 to 2.0ng/ml). Taking these data into consideration, we diagnosed him as having digitalis intoxication. Direct hemoperfusion (DHP) was initiated. It was performed three times. His general condition gradually improved after treatment. He was discharged after his sixtyth day in the hospital. From the viewpoint of safety and effectiveness, DHP is a good therapy for digitalis intoxication.
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