臨牀透析 Vol.18 No.6(9)


特集名 透析患者の肝・胆・脾・膵の病変
題名 腹膜透析患者における急性膵炎
発刊年月 2002年 06月
著者 吉田 英昭 札幌医科大学第二内科
著者 浦 信行 札幌医科大学第二内科
【 要旨 】 わが国の急性膵炎の発症頻度は年間14,500例と推定されている.慢性腎不全患者,とくに腹膜透析患者では健常人に比較して発症頻度が高いという報告が多い.急性膵炎の約70%は軽症例で2~3日の絶食により1週間前後で軽快するが,中等症や重症例では致死率が高くなり,集中した全身管理が必要となる.腎不全患者では正常であっても膵酵素が上昇していることがあり,とくに腹膜透析患者の腹痛は細菌性腹膜炎をまず疑い対処されることもあって,時として急性膵炎の診断を難しくする.治療は腎不全の有無にかかわらず,臨床診断基準,重症度判定基準を参考にしながら,内科的治療を中心とし,外科治療は合併症に対して行われることが多い.
Theme Disease of Liver, Gallbladder, Spleen, and Pancreas in Dialysis Patients
Title Acute pancreatitis in patients receiving peritoneal dialysis
Author Hideaki Yoshida Second Department of Internal Medicine, Sapporo Medical University School of Medicine
Author Nobuyuki Ura Second Department of Internal Medicine, Sapporo Medical University School of Medicine
[ Summary ] Approximately 14,500 new acute pancreatitis patients have been registered annually in Japan. The incidence of acute pancreatitis tends to be higher in end-stage renal failure patients, especially in patients receiving peritoneal dialysis (CAPD), than in normal subjects. The clinical courses for about 70% of the patients with this disease are very good and the patients recover without any complications after receiving not per os (NPO) therapy for several days. On the other hand, patients who fail to moderate or severe pancreatitis are often required intensive care medicine because of high mortality. CAPD patients are sometimes difficult to make diagnose because abdominal pain in CAPD patients is usually treated as a sign of bacterial peritonitis at first. It is well known that pancreatic enzymes are often elevated in cases of chronic renal failure and this fact may also lead to misdiagnose. Even in case of chronic renal failure, severe acute pancreatitis is treated intensively with internal medicines, according to specific guidelines and surgical treatment is sometimes required to treat complications.
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