| [ Summary ] |
In a new criteria for hemodialyzers and filters proposed by JSDT 2000, internal filtration enhanced dialyzers are given the classification "IIIa" as are hemodiafilters for low volume replacement purposes. The minimum performance requirements for the IIIa category are that the clearances to urea, creatinine and beta2-microglobulin under 30ml/min of ultrafiltration are no less than 165, 140 and 40 ml/min, respectively, at blood and dialysate flow rates of 200 and 500ml/min. The clinical indications for IIIa category treatment is targeted for symptoms that cannot be relieved by II category divices including symptoms of dialysis related amyloidosis, hypotension during treatment, pruritus, insomnia, irritable peripheral neuropathy, erythropoietin-unresponsive anemia, malnutrition and other manifestations severely impinging on QOL. The IIIa devices are expected to become the standard for blood purification treatment for years to come. |