| Theme |
Adequate Dialysis : Current Topics in Kinetic Modeling |
| Title |
Kinetic modeling in peritoneal dialysis |
| Author |
Akihiro C. Yamashita |
Department of Materials Science and Engineering, Shonan Institute of Technology |
| [ Summary ] |
Kinetic models for peritoneal dialysis (PD) are based on a compartment model. Two different methods of describing the rate of mass transfer at the peritoneum are present; the classic model in which an overall mass transfer-area coefficient (MTAC) plays a significant role and a new model in which the three pore theory is involved. Simplified equations are also available to calculate MTAC for evaluating peritoneal function for small solutes. Use of specific software is necessary when the latter model is incorporated. In CAPD therapy, since the rate of solute generation always equals that of solute removal, clinical prescriptions may be considered using this relationship. A new treatment modality has been introduced by combining PD and hemodialysis (HD) to enhance the quantity of both solute and fluid removal. In this new modality, the HD schedule is important when PD is not in use. A new kinetic model in which PD and HD models are combined may be useful for simulation. |