| Theme |
Multiple Organ Failure and Blood Purification Therapy |
| Title |
Pathophysiology and diagnosis of multiple organ disfunction syndrome |
| Author |
Shigeatsu Endo |
Critical Care and Emergency Center, Iwate Medical University |
| Author |
Shigeru Taniguchi |
Critical Care and Emergency Center, Iwate Medical University |
| Author |
Katsuya Inada |
Department of Bacteriology, Iwate Medical University |
| Author |
Takae Kawamura |
Department of Anesthesiology, Iwate Medical University |
| Author |
Nobuhiro Sato |
Department of Surgery, Iwate Medical University |
| [ Summary ] |
The systemic inflammatory response is seen in association with various clinical conditions. Tumor necrosis factor, or other cytokines play an important role in systemic inflammatory response syndrome (SIRS). A frequent complication of SIRS is the development of organ system dysfunction, such as ARDS, DIC, renal failure, shock, and multiple organ dysfunction. Inflammatory cytokines become a trigger for the production of phospholipase A2, eicosanoids, NO, endothelin-1, thrombomodulin, polymorphonuclear leukocyte, and adhesion molecules. These mediators cause complex pathophysiologic condition in SIRS. |