| Theme |
Uremic Toxins |
| Title |
Uremic neuropathy and uremic toxins |
| Author |
Takashi Hasegawa |
Department of Internal Medicine II, The Jikei University School of Medicine |
| Author |
Tsuyoshi Sakamoto |
Department of Internal Medicine II, The Jikei University School of Medicine |
| Author |
Yoshindo Kawaguchi |
Department of Internal Medicine II, The Jikei University School of Medicine |
| Author |
Tatsuo Hosoya |
Department of Internal Medicine II, The Jikei University School of Medicine |
| [ Summary ] |
In uremic neuropathy, axonal degeneration has been demonstrated to be a major pathological finding. Another report suggests that the pathological feature of uremic neuropathy lies primarily in segmental demyelination due to Schwann cell dysfunction.
Uremic toxins may be a factor in uremic neuropathy, but the exact causes are still unknown. Myoinositol, which is one of the representative uremic toxins, influences signal transduction in the phosphatidylinositol pathway and damages Schwann cells by combining with serum substances. The effects of hemodialysis with high performance membranes, including the polysulfone membrane, improve many uremic symptoms. However, whether hemodialysis has any advantages for uremic neuropathy is a very important issue. |