| Theme |
Recent Advances in Acute Renal Failure: pathogenesis and treatment |
| Title |
Dialyzers and hemofilters for acute renal failure patients |
| Author |
Michio Mineshima |
Kidney Center, Tokyo Women's Medical College |
| [ Summary ] |
Selection of dialyzer and operating conditions in blood purification therapies for acute renal failure patients has not yet been established. Adequate treatment doses should be determined for each patient. Aqueous solution testing was introduced to clarify the relationship between solute clearance and operating conditions such as blood flow rate (QB), dialysate flow rate (QD) and filtrate flow rate (QF). From these results, it was clear that urea and creatinine clearance (CL) values strongly depend on the QB and QD values and vitamin B12 and inulin CL values on the QF value.
In a clinical situation, a setting of the QF value was restricted to the patient's QB value and the QD value should be determined more than 2 times as the QB value. Adequate treatment doses were also determined by the target solute concentration level and generation rate of the patient. Monitoring the amount of solute removed is recommended for following pathophysiologic change in the patient. |