臨牀透析 Vol.14 No.2(3)


特集名 急性腎不全の血液浄化法
題名 急性腎不全を対象とした血液浄化法の選択と適応,適正透析量の評価
発刊年月 1998年 02月
著者 西原 学宣 済生会八幡総合病院腎センター
著者 中本 雅彦 済生会八幡総合病院腎センター
【 要旨 】 急性腎不全患者に血液浄化法を行う場合,循環動態が安定していれば間欠的な血液透析を選択する.循環動態が不安定な場合は持続的血液浄化法を選択する.持続的血液浄化法は看護,モニター体制の不備な施設では行うべきでない.大量の除水を必要とせず,しかも,強力な溶質除去を必要としない場合,腹膜透析も可能である.血液透析ではBUNが80~100mg/dl以上にならぬよう保つことが好ましいが,たとえ,これ以上強力な血液透析を行っても合併症頻度と予後には影響を与えない.持続的血液濾過では正常な糸球体濾過量(GFR)の10%以上の濾過を目指すが,異化亢進のため溶質(BUN)除去不足になる場合は持続的血液濾過透析を行う.
Theme Recent Advances in Acute Renal Failure: pathogenesis and treatment
Title Renal replacement therapy in acute renal failure : choice of modality and evaluation of intensity
Author Gakusen Nishihara Kidney Center, Saiseikai Yahata Hospital
Author Masahiko Nakamoto Kidney Center, Saiseikai Yahata Hospital
[ Summary ] If the patient with acute renal failure is hemodynamically stable, hemodialysis should be performed. If the patient is hemodynamically unstable, continuous renal replacement therapy (CRRT) should be performed. CRRT should be performed where one-to-one nursing is available. If the patient is hemodynamically unstable, requires modest clearance, and does not require large volume of ultrafiltration, peritoneal dialysis may be performed. It has been suggested that patient outcome can be improved to maintain BUN under 80 to 100 mg/dl. Recent studies have not been able to document significant benefit of more intensive dialysis. With CRRT, such as continuous hemofiltration, the aim is a clearance above 10% of the normal glomerular filtration rate. If the patient is hypercatabolic and solute removal is important, continuous hemodiafiltration is preferable.
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