| Theme |
Polyposis of the colon and rectum, and other related conditions : hereditary colorectal cancer |
| Title |
Peutz-Jeghers syndrome -- uterine cervical adenocarcinoma (adenoma malignum) |
| Author |
Yasuko Koyamatsu |
Department of Obstetrics and Gynecology, Kyoundo Hospital, Sasaki Foundation / Department of Obstetrics and Gynecology, Faculty of Medicine, Saga University |
| Author |
Masaru Sakamoto |
Department of Obstetrics and Gynecology, Kyoundo Hospital, Sasaki Foundation |
| Author |
Tsukasa Akiya |
Department of Obstetrics and Gynecology, Kyoundo Hospital, Sasaki Foundation |
| Author |
Makoto Nakano |
Department of Obstetrics and Gynecology, Kyoundo Hospital, Sasaki Foundation |
| Author |
Tetsuya Muroya |
Department of Obstetrics and Gynecology, Tokyo Kenbikyo Hospital |
| Author |
Takeo Iwama |
Department of Surgery, Kyoundo Hospital, Sasaki Foundation |
| Author |
Tsuyoshi Iwasaka |
Department of Obstetrics and Gynecology, Faculty of Medicine, Saga University |
| [ Summary ] |
Patients with Peutz-Jeghers syndrome (PJS) are at increased risk of developing various neoplasms in the female genital tract. The most well known gynecological disease associated with PJS is adenoma malignum (AM) of the uterine cervix. This is defined as an unusually well differentiated adenocarcinoma with glandular cell morphology very close to that of normal cells, and so may be difficult to diagnose histologically. AM often has an unfavorable prognosis, because of the difficulties with initial diagnosis and treatment.
Recently, immunohistochemical examination revealed that antibodies designed as HIK1083 are reported to produce positive results for AM. This monoclonal antibody specifically recognizes an epitope present in a neutral mucin derived from the surface of gastric gland mucosal cells. For a definitive diagnosis of this disease, we should do appropriate and specific examinations employing staining to not miss this condition, and should make efforts to prevent its progression. |