| Theme |
Colorectal cancer in ulcerative colitis |
| Title |
Endoscopic diagnosis of colitic cancer -- Significance of target biopsies |
| Author |
Yasushi Iwao |
Division of Gastroenterology, Department of Internal Medicine, Keio University School of Medicine |
| Author |
Katsuyoshi Matsuoka |
Division of Gastroenterology, Department of Internal Medicine, Keio University School of Medicine |
| Author |
Haruhiko Ogata |
Division of Gastroenterology, Department of Internal Medicine, Keio University School of Medicine |
| Author |
Toshifumi Hibi |
Division of Gastroenterology, Department of Internal Medicine, Keio University School of Medicine |
| Author |
Hirotoshi Hasegawa |
Department of Surgery, Keio University School of Medicine |
| Author |
Yoshinori Sugino |
Department of Diagnostic Radiology, Keio University School of Medicine |
| Author |
Makio Mukai |
Department of Diagnostic Pathology, Keio University School of Medicine |
| [ Summary ] |
An increased risk of developing colorectal cancer has been reported in pateients with long standing ulcerative colitis and cancer surveillance is recommended. Because it is difficult to detect dysplasia occuring in the flat mucosa, current practice guidelines recommend surveillance programs using random biopsy specimens. Recently, advances in high resolution endoscopy and chromoendoscopy have improved the diagnosis of flat dysplastic lesions. We emphasize that careful examinations, using chromoscopy and targeted biopsies of suspicious lesions is a more effective surveillance strategy than taking random biopsies. |