| [ Summary ] |
We studied the clinicopathological and immunohistochemical features of 143 cases of primary small and large intestinal non-Hodgkin's lymphoma (NHL) in Japanese patients who were seen between 1981 and 2000. The new World Health Organization (WHO) classification was used to classify NHL. The patients included 109 males and 34 females, with an average age of 54.1 years. Tumour sites were as follows : ileocecum (n=51, 35.7%), ileum (n=29, 20.3%), rectum (n=13, 9.1%), and duodenum (n=11, 7.7%). Macroscopically, 124 cases (86.7%) were classified as of the tumorous-type, 12(8.4 %), as the diffuse infiltration-type (erosion, superficial ulceration), 5 cases (3.5%) as the polyposis-type, and only 2 cases (1.4%) as the ulceration-type. Immunohistochemically, 122 lesions (85.3%) were of the B-cell phenotype and 21 lesions (14.7%) were of the T-cell phenotype. According to the WHO classification, of the B-cell lymphomas, 84 cases (68.9%) were large cell, 16 (13.1%) were Burkitt, 10 (8.2%) were marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT), and 7 (5.7%) were mantle cell tumours. Among the T-cell lymphomas, 15 (71.4%) were of unspecified type, 2 (9.5%) were NK - type, 2 were anaplastic large cell lymphomas, 1 was lymphoblastic, and 1 was an adult T-cell leukaemia lymphoma. The survival rate for T-cell lymphomas was worse than for B-cell lymphomas. Among the B-cell lymphomas, mantle cell lymphoma tended to have a worse prognosis, whereas MALT lymphomas had a better prognosis than other B-cell tumour types. |