| [ Summary ] |
We discussed the effectiveness of hepatic locoregional chemotherapy with exclusive of weekly high doses of 5 FU through the hepatic artery (WHF) on unresectable hepatic metastases patients with colorectal cancer. Hepatic arterial infusion chemotherapy (HAIC), using 5 FU (250 to 500mg/body) and CDDP (5 to 10mg/body), obtained a response rate of 70% and a median survival time of 23.5 months in our 10 cases. Serious toxicities were recognized in four cases and specific toxicity caused by HAIC, liver abscess due to cholangitis, occurred in two cases. HAIC using IL-2, 5 FU and MMC has also been reported to be another hopeful protocol, with a response rate of 66.7%. Isolated hepatic chemoperfusion is in progress as another form of hepatic locoregional chemo therapy. The method can be divided broadly intotwo categories. One is percutaneous isolated hepatic perfusion under hepatic venous isolation and charcoal hemoperfusion without any surgical procedure. The other is isolated hepatic hyperthermo chemoperfusion via a completely isolated vascular recirculating perfusion circuit, using a surgical procedure. It would be problem to be solved that all of locoregional chemotherapy can effectively control bepatic lesions, but not extrahepatic ones. |