INTESTINE Vol.7 No.3(2-3)

特集名 大腸癌肝転移の画像診断と治療
題名 画像診断 (3) PET
発刊年月 2003年 05月
著者 加藤 隆司 国立長寿医療研究センター生体機能研究部
著者 伊藤 健吾 国立長寿医療研究センター生体機能研究部
【 要旨 】 要旨はありません。
Theme Recent advances in the diagnostic imaging and the treatment of liver metastates from colorectal cancer
Title PET
Author Takashi Kato Department of Biofunctional Research, National Institute for Longevity Sciences
Author Kengo Ito Department of Biofunctional Research, National Institute for Longevity Sciences
[ Summary ] Approximately 50% of patients diagnosed with colorectal cancer will develop liver metastases with five years. The five year survival rate after hepatic resection is about 40%. Many patients are thought to have been harboring tumor foci unrecognized by X-ray CT at the time of liver resection. Positron emission tomography (PET) with [F-18] FDG (fluorodeoxyglucose) is a sensitive diagnostic tool based on visualizing increased glucose metabolic activity in tumor tissue. The sensitivity, accuracy, and specificity in the diagnoses for colorectal liver metastases with FDG PET seans shown in a meta-analysis was 96.3%, 99.0, and 97.7% respectively. X-ray CT, even a helical CTs, can often not differentiate metastases and benign diseases when the lesion is small. FDG PET has produced higher over-all accuracy in the diagnoses of liver metastases than any other imaging method, although it's sensitivity is reduced in cases with small lesions. FDG PET scans can also improve the therapeutic management of patients with liver metastases by detecting unsuspected extra-hepatic metastases. FDG PET scans decrease recurrence rates in patients undergoing hepatic resection by avoiding inappropriate operations. FDG PET scanning has a strong impact on clinical management of patients with colorectal liver metastases.