| Theme |
Advanced colorectal cancer arisen from LST (laterally spreading tumor) |
| Title |
Clinico-pathological study of advanced colorectal cancers developing from laterally spreading tumors-predictions on natural history of laterally spreading tumors non-granular type |
| Author |
Satoshi Abe |
Department of Gastroenterology, Juntendo University, School of Medicine |
| Author |
Takeshi Terai |
Department of Gastroenterology, Juntendo University, School of Medicine |
| Author |
Naoto Sakamoto |
Department of Gastroenterology, Juntendo University, School of Medicine |
| Author |
Hiroaki Fujii |
Department of Pathology, Juntendo University, School of Medicine |
| Author |
Shu Hirai |
Department of Pathology, Tokyo Rinkai Hospital |
| Author |
Kazuko Beppu |
Department of Gastroenterology, Juntendo University, School of Medicine |
| Author |
Yoshiko Inooku |
Department of Gastroenterology, Juntendo University, School of Medicine |
| Author |
Osamu Kobayashi |
Department of Gastroenterology, Juntendo University, School of Medicine |
| Author |
Taro Osada |
Department of Gastroenterology, Juntendo University, School of Medicine |
| Author |
Keiichi Ohtaka |
Department of Gastroenterology, Juntendo University, School of Medicine |
| Author |
Akihito Nagahara |
Department of Gastroenterology, Juntendo University, School of Medicine |
| Author |
Toshifumi Ohkusa |
Department of Gastroenterology, Juntendo University, School of Medicine |
| Author |
Hiroto Miwa |
Department of Gastroenterology, Juntendo University, School of Medicine |
| Author |
Taturo Ogiwara |
Department of Gastroenterology, Juntendo University, School of Medicine |
| Author |
Nobuhiro Sato |
Department of Gastroenterology, Juntendo University, School of Medicine |
| [ Summary ] |
Recently, laterally spreading tumors (LST) of the colon and rectum have been studied endoscopically and have been reported at many cases. However, there is no literature about the natural history of LST.
We classified LSTs as being either the granular type (LST-G) or non-granular type (LST-NG), and investigated their biological characteristics, comparing LST-G to LST-NG. There were some cases of LST-G over 30mm in size, on the other hand, the number of LST-NG lesions of the same size was low. Although we have experienced few advanced cancers developing from LST-NG, we have sometimes detected advanced cancers from LST-G. The size of advanced cancers from LST-NG was approximately 20mm in size. There were cases of LST-G located in the cecum, ascending colon and rectum, on the other hand, LST-NG were located in the cecum, ascending colon and transverse colon. Also, there were advanced cancers of LST-NG located in the same area of the colon. These results suggested that LST-NG developed into advanced cancer rapidly when its size was approximately 20mm in the right side of colon. Therefore, it was thought that the structure of LST-NG might have been destroyed during the development of advanced cancers. |