| Theme |
Colorectal cancer screening and surveillance -- Prospects towards standardization from new findings |
| Title |
Points of medical care for familial adenomatous polyposis and Lynch syndrome based on the JSCCR Guideline 2020 for Clinical Practice of Hereditary Colorectal Cancer |
| Author |
Takeshi Nakajima |
Department of Clinical Genetics, Cancer Institute Hospital of Japanese Foundation for Cancer Research |
| [ Summary ] |
JSCCR guidelines 2020 for the Clinical Practice of Hereditary Colorectal Cancer was republished. These guidelines primarily dealt with reports on familial adenomatous polyposis (FAP) and Lynch syndrome. The diagnosis of Lynch syndrome in patients remain somewhat difficult because there is no definite clinical phenotype of Lynch syndrome, as opposed to FAP. In addition, genetic testings based on the APC gene and mismatch repair genes required for definitive diagnosis in each patient is not covered by Japanese health insurance. The fact that the diagnostic procedure recommended in the guideline is not covered by Japanese health insurance represents a major issue. However, it is important to build a medical care system that combines free medical care. In addition, there are many atypical cases encountered clinically. In this report I would like to present the clinical cases that I have worked on, with a particular emphasis on the points of medical care. |