| [ Summary ] |
In this article, the histopathological diagnosis of de novo colorectal cancer is introduced. In a retrospective review of 21 cases of superficial colorectal tumors with depressed areas, 14, 4, and 3 cases were diagnosed as adenocarcinoma (de novo cancer), adenoma, and adenocarcinoma with an adenoma component, respectively. The important histological findings for the discrimination of adenocarcinoma from adenoma were the shape of the neoplastic crypts, cellular differentiation from the top of the mucosa toward the basal side, nuclear chromatin pattern, nucleoli, shape of the nuclei, and nuclear polarity. Herein, eight representative lesions are demonstrated, and the historical and practical issues in de novo cancer of the colon and rectum are discussed. |