| Theme |
Systemic disease-associated intestinal involvement -- Intestinal Behçet's disease and its differential diagnosis |
| Title |
Chronic enteropathy associated with SLCO2A1 gene (CEAS) and cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) |
| Author |
Jun Urushikubo |
Division of Gastroenterology, Department of Internal Medicine, Iwate Medical University |
| Author |
Shunichi Yanai |
Division of Gastroenterology, Department of Internal Medicine, Iwate Medical University |
| Author |
Takayuki Matsumoto |
Division of Gastroenterology, Department of Internal Medicine, Iwate Medical University |
| [ Summary ] |
Chronic nonspecific multiple ulcers of the small intestine (CNSU) have been reported as an enteropathy characterized by multiple small intestinal ulcers of nonspecific histology. Recently, CNSU has been found to be caused by homozygous or compound heterozygous mutation of the SLCO2A1 gene, which encodes a prostaglandin transporter. Therefore, the disease has been referred to as chronic enteropathy associated with SLCO2A1 gene (CEAS). There has also been a description of an enteropathy, referred to as cryptogenic multifocal ulcerative stenosing enteritis (CMUSE), in which mutations of cPLA2α pathognomonic event. These findings suggest that there may be a clinical entity of enteropathy associated with prostaglandins in humans. These diseases should be considered as being differential diagnoses of intestinal Behçet's disease and simple ulcer of the small intestine. |