| Theme |
Systemic disease-associated intestinal involvement -- Intestinal Behçet's disease and its differential diagnosis |
| Title |
Simple ulcer and intestinal lesions associated with trisomy 8: differential diagnoses of intestinal Behçet's disease |
| Author |
Yuta Fuyuno |
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| Author |
Atsushi Hirano |
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| Author |
Junji Umeno |
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| Author |
Shin Fujioka |
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| Author |
Tomohiko Moriyama |
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| Author |
Takehiro Torisu |
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| Author |
Motohiro Esaki |
Department of Endoscopic Diagnostics and Therapeutics, Saga University Hospital |
| [ Summary ] |
Differential diagnosis of intestinal Behçet's disease (BD) includes simple ulcer (SU) and intestinal lesions associated with trisomy 8. SU is a morphological diagnosis used for patients with a typical lesion of the intestinal BD that presents a undermining ulcer in the ileocecum but does not meet the criteria for complete or incomplete BD. Cases of suspicious BD fall into the category of SU, and in such cases, they cannot receive the anti-TNFα antibody therapies. On the other hand, in the case of trisomy 8 positive myelodysplastic syndrome, they often show punched-out or undermining ulcers that closely resemble intestinal BD or SU. Although there is no clear difference in endoscopic findings, it has been suggested that responsiveness to medical treatment varies greatly. |