| Theme |
Molecular biology of colorectal tumors |
| Title |
Treatment of colorectal cancer and molecular biology |
| Author |
Kenta Kawasaki |
Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University |
| Author |
Yasuo Hamamoto |
Keio Cancer Center, School of Medicine, Keio University |
| [ Summary ] |
Colorectal cancer is a devastating disease with high morbidity and mortality rates. It has long been studied for its molecular factors including its relationship to oncogenesis. In fact, molecular targeted therapy obtained through research has prolonged overall survival rates by more than 10 months compared to cytotoxic treatment alone. Further advances in molecular biology have provided for the detection of rare mutations which have been reported in less than 5 % of cases. They are expected to prolong overall survival rates due to colorectal cancer in the near future. We outline the contributions of molecular biology to the development of chemotherapy for colorectal cancer and summarize novel therapeutic targets and clinical applications. |