INTESTINE Vol.22 No.1(8)


特集名 IBD関連大腸腫瘍の診断・治療update
題名 潰瘍性大腸炎関連大腸腫瘍の治療方針と経過観察
発刊年月 2018年 01月
著者 樋田 信幸 兵庫医科大学炎症性腸疾患学講座内科部門
著者 中村 志郎 兵庫医科大学炎症性腸疾患学講座内科部門
【 要旨 】 潰瘍性大腸炎に発生するdysplasiaの自然史は十分に解明されておらず,診断後の取り扱いに関する見解は一致していない.元来,内視鏡で認識されるdysplasiaはDALMと呼ばれ,手術適応とされてきた.しかし,DALMには多様な病変が混在しており,その取り扱いに混乱が生じていたため,近年発表されたSCENIC consensus statementではDALMの概念を排除した新たな形態用語が提唱されている.SCENICでは内視鏡切除が可能な境界明瞭なpolypoid dysplasiaに対しては大腸全摘よりも内視鏡切除後のサーベイランス継続が推奨されているが,そのエビデンスは低い.dysplasiaの患者に大腸全摘術を行うか,内視鏡治療や経過観察を行うかについては,個々の患者の病変形態,異型度などを考慮して,慎重に決定する必要がある.
Theme Recent advance in diagnosis and management of colorectal tumors associated with inflammatory bowel disease
Title Management and follow up of ulcerative colitis associated colorectal neoplasia
Author Nobuyuki Hida Division of Internal Medicine, Department of Inflammatory Bowel Disease, Hyogo College of Medicine
Author Shiro Nakamura Division of Internal Medicine, Department of Inflammatory Bowel Disease, Hyogo College of Medicine
[ Summary ] The natural history of dysplasia in patients with ulcerative colitis (UC) is poorly understood, method to best manage it remain controversial. Traditionally, the discovery of endoscopically visible dysplasia, so called "dysplasia associated lesions or mass (DALM)" led to colectomies. However, DALM can be very confusing as indications not specific. The recently published SCENIC consensus statement recommended abandoning the term "DALM", and developed a new set of terminology for UC associated neoplastic lesions. The SCENIC panelists also recommend that surveillance colonoscopies rather than colectomies be recommended for removal of endoscopically resectable polypoid dysplasia with distinct borders, although the available evidence is of very low quality. Patients with dysplasia should either decide to undergo colectomies, endoscopic resection, or close colonoscopic follow-ups, depending on individual situations such as the form and degree of dysplasia.
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