INTESTINE Vol.22 No.1(3)


特集名 IBD関連大腸腫瘍の診断・治療update
題名 拡大内視鏡(色素・IEE)による潰瘍性大腸炎関連大腸腫瘍の診断
発刊年月 2018年 01月
著者 岡 志郎 広島大学病院消化器・代謝内科
著者 田中 信治 広島大学病院内視鏡診療科
著者 松本 健太 広島大学病院消化器・代謝内科
著者 林 亮平 広島大学病院内視鏡診療科
著者 上野 義隆 広島大学病院内視鏡診療科
著者 茶山 一彰 広島大学病院消化器・代謝内科
【 要旨 】 潰瘍性大腸炎(UC)関連腫瘍は,病変表層および背景粘膜が炎症の影響により本来整であるはずの非腫瘍粘膜も不整像を呈するため,孤発性大腸腫瘍に用いられている既存の拡大内視鏡分類では評価が難しいことが課題である.われわれの検討では,色素拡大観察では周囲粘膜との比較を指標とした「pit密度高」「pit辺縁不整」,NBI拡大観察ではsurface patternの「不整」「無構造」がUC関連腫瘍の診断に有用である可能性が示された.UC患者のサーベイランス内視鏡検査に拡大観察を併用することは,狙撃生検によるUC関連腫瘍の診断精度向上に貢献することが期待される.
Theme Recent advance in diagnosis and management of colorectal tumors associated with inflammatory bowel disease
Title Usefulness of magnifying colonoscopy for ulcerative colitis associated neoplasia
Author Shiro Oka Department of Gastroenterology and Metabolism, Hiroshima University Hospital
Author Shinji Tanaka Department of Endoscopy, Hiroshima University Hospital
Author Kenta Matsumoto Department of Gastroenterology and Metabolism, Hiroshima University Hospital
Author Ryohei Hayashi Department of Endoscopy, Hiroshima University Hospital
Author Yoshitaka Ueno Department of Endoscopy, Hiroshima University Hospital
Author Kazuaki Chayama Department of Gastroenterology and Metabolism, Hiroshima University Hospital
[ Summary ] Ulcerative colitis (UC) associated neoplasia is an intestinal tract condition that can affect the life expectancy of UC patients. The current pit pattern classification system (Kudo-Tsuruta classification) may not be fully applicable in UC patients, because the pits characteristics of UC can become elongated or irregular, depending on the degree of inflammation. Our data showed that high residual density of pits and irregular pit margins were useful to differentiate between colitis-associated neoplastic and non-neoplastic lesions. An advantage of narrow band imaging (NBI) magnification is that visualization can be achieved without dye spraying, which potentially reduces the cost of examination and time consumed to diagnose UC associated neoplasias. The surface pattern, as determined by NBI magnifying colonoscopy, is a useful finding for differentiation between colitis-associated neoplastic and non-neoplastic lesions. Differentiating dysplastic lesions from non-dysplastic lesions can potentially help endoscopists perform smarter biopsies and increase diagnostic yield.
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