| Theme |
Impacts of intestinal microbiota |
| Title |
Intestinal microbiota in obesity and type 2 diabetes |
| Author |
Junichiro Irie |
Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, School of Medicine, Keio University |
| Author |
Hiroshi Itoh |
Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, School of Medicine, Keio University |
| [ Summary ] |
Irregular lifestyle habits such as insufficient sleep and an unbalanced diet induce a reduction of the number of bacterial genes (bacterial richness), leading to "dysbiosis," systemic chronic inflammation, and alteration of the intestinal hormone secretion. These changes result in obesity and type 2 diabetes. Regular eating habits maintain the homeostasis of intestinal microbiota and prevent the development of lifestyle-related diseases. Novel therapeutics targeting intestinal microbiota, such as probiotics and medication for gastrointestinal tract has been investigated and expected for lifestyle-related diseases. |