| [ Summary ] |
Recent advances in studies pertaining to irritable bowel syndrome (IBS) have demonstrated that microbiota might play a crucial role in its pathophysiology. IBS is triggered by acute bacterial infection of the gut. Gut microbiota identifi ed in IBS patients differ from organisms found in healthy controls. Fecal concentration of short chain fatty acids is proportional to gastrointestinal symptoms, quality of life, and Factor 3 on the alexithymia scale. Stress alters the composition of gut microbiota, increases mucosal permeability, and sensitizes visceral perception thereby mimicking features of IBS. Interventions directed toward gut microbiota not only improve IBS symptoms but are also seen to improve negative emotions including depression. Further analyses of gut microbiota in IBS are warranted. |