INTESTINE Vol.20 No.3(2)

特集名 消化管ポリポーシス─診断と治療の進歩
題名 家族性大腸腺腫症─最新の治療を中心に
発刊年月 2016年 05月
著者 石川 秀樹 京都府立医科大学分子標的癌予防医学大阪研究室
【 要旨 】 これまで,家族性大腸腺腫症患者における大腸癌の発生を予防する方法は外科的大腸全摘術のみであった.最近になり,大腸全摘術を避ける,または手術時期を遅らせるために,薬を用いて大腸癌発生を予防する化学予防や,内視鏡的にポリープを徹底的に摘除する治療法の研究が行われている.
Theme Gastrointestinal polyposis -- progress in the diagnosis and treatment
Title Familial adenomatous polyposis : prevention of colorectal cancer
Author Hideki Ishikawa Department of Molecular-Targeting Cancer Prevention, Kyoto Prefectural University of Medicine
[ Summary ] Until recently, total colectomy was the only option to prevent progression from familial adenomatous polyposis (FAP) to colon cancer. To avoid colectomy or prolong the time to surgery, studies have been conducted on chemoprevention for suppression of the growth of colorectal polyps and on treatment with endoscopic polypectomy.
This report presents the results of clinical studies with non-steroidal anti-inflammatory drugs such as sulindac, celecoxib, and aspirin on chemoprophylaxis against progression from FAP to colon cancer, and recent progress of research on thorough endoscopic polypectomy.
Chemoprevention therapy and endoscopic polypectomy have not been sufficiently studied for clinical use in FAP, but may become practical options for treatment of some types of FAP in the near future.