| Theme |
The roll of superficial depressed type on developmental process of colorectal cancer |
| Title |
Genetic abnormalities in IIc type early colorectal cancer |
| Author |
Shozo Baba |
Second Department of Surgery, Hamamatsu University School of Medicine |
| [ Summary ] |
Superficial depressed type of early colorectal cancer (IIc type) was first recognized radio logically by Kariya in 1977. Since then many cases have been reported in Japan by various endoscopists. These tiny depressed lesions can be candate lesions of de novo cancers, however, detailed genetic analysis has not been elucidated. As for colorectal carcinogenesis, it is now known that there are considered to be alternative genetic pathways besides adenoma in the carcinoma sequence. It has been now clarified that the incidence of K-ras mutation in IIc type of early cancer is very low. Genes playing a key role in various carcinogenetic pathways were discussed. |