| Theme |
Intestinal inflammation in small bowel |
| Title |
Drug induced small bowel injury [NSAIDs (aspirin)] |
| Author |
Shotaro Umezawa |
Department of Gastroenterolog and Hepatology, Yokohama City University School of Medicine |
| Author |
Hiroki Endo |
Department of Gastroenterolog and Hepatology, Yokohama City University School of Medicine |
| Author |
Eiji Sakai |
Department of Gastroenterolog and Hepatology, Yokohama City University School of Medicine |
| Author |
Atsushi Nakajima |
Department of Gastroenterolog and Hepatology, Yokohama City University School of Medicine |
| [ Summary ] |
NSAIDs, including aspirin, are the most widely used drugs in clinical practice. It is especially evident that aspirin is useful for primary and secondary prevention of cardiovascular and thrombotic cerebrovascular events. On the other hand, use of NSAIDs is reported to be associated with a risk of not only serious upper gastro-intestinal adverse events but also lower gastro-intestinal injuries. The development of enteroscopy, including capsule endoscopy and balloon endoscopy, has made it possible to clarify the role of NSAIDs/aspirin induced small bowel injury. However, reports concerning these conditions are limited and it mostly remains unexplained. In recent basic and clinical research, it has been reported that PPIs increase the risk of these conditions. In terms of treatment, medications, including probiotics, may be considered possible therapeutic agents. It is necessary to recognize patients at high risk and establish preventive and treatment studies through a large number and randomized controlled trials. |