INTESTINE Vol.18 No.6(6)


特集名 腸管ベーチェット病と単純性潰瘍
題名 腸管ベーチェット病・単純性潰瘍の上部消化管病変
発刊年月 2014年 11月
著者 高木 靖寛 福岡大学筑紫病院消化器内科
著者 安川 重義 福岡大学筑紫病院消化器内科
著者 平井 郁仁 福岡大学筑紫病院消化器内科
著者 矢野 豊 福岡大学筑紫病院消化器内科
著者 久部 高司 福岡大学筑紫病院消化器内科
著者 松井 敏幸 福岡大学筑紫病院消化器内科
著者 岩下 明德 福岡大学筑紫病院病理部
著者 池田 圭祐 福岡大学筑紫病院病理部
著者 田邉 寛 福岡大学筑紫病院病理部
著者 二見 喜太郎 福岡大学筑紫病院外科
【 要旨 】 腸管ベーチェット病（intestinal Behçet's disease；腸管BD）および単純性潰瘍（simple ulcer；SU）の上部消化管病変について自験例と文献報告例の検討を行い概説した．潰瘍やびらんなどの胃・十二指腸病変は薬剤や他の要因との関連があり今後の検討が必要である．しかし，食道病変は6.7～18.5％の頻度でみられ，回盲部の定型的潰瘍に類似した病変も多く特徴的であり，積極的な上部消化管検査で食道病変を検索し重要視することは腸管BD・SUの診断向上に寄与すると考えられる．
Theme Intestinal Behçet's disease and simple ulcer of the intestine
Title Upper gastrointestinal involvement in patients with Behçet's disease and simple ulcers
Author Yasuhiro Takaki Department of Gastroenterology, Fukuoka University Chikushi Hospital
Author Shigeyoshi Yasukawa Department of Gastroenterology, Fukuoka University Chikushi Hospital
Author Fumihito Hirai Department of Gastroenterology, Fukuoka University Chikushi Hospital
Author Yutaka Yano Department of Gastroenterology, Fukuoka University Chikushi Hospital
Author Takashi Hisabe Department of Gastroenterology, Fukuoka University Chikushi Hospital
Author Toshiyuki Matsui Department of Gastroenterology, Fukuoka University Chikushi Hospital
Author Akinori Iwashita Department of Pathology, Fukuoka University Chikushi Hospital
Author Keisuke Ikeda Department of Pathology, Fukuoka University Chikushi Hospital
Author Hiroshi Tanabe Department of Pathology, Fukuoka University Chikushi Hospital
Author Kitarou Futami Department of Surgery, Fukuoka University Chikushi Hospital
[ Summary ] The most frequent site of gastrointestinal involvement in patients with Behçet's disease (BD) and simple ulcer (SU) is ileocecal region, and the most common manifestation of these lesion is deep punched-out ulcers. On the other hand, it is known that upper gastrointestinal involvement occurs in a small number of patients with BD and SU. Accordingly, we summarized the characteristics of upper gastrointestinal lesions in patients with intestinal BD and SU by reviewing the clinical findings of our own cases and those provided in medical literature. The prevalence of esophageal involvement was ranged from 6.7 % to 18.5 %. The most characteristic manifestation in the esophagus was round or oval shaped solitary or multiple ulcers which resembled the typical ileocecal ulcers. In addition, some cases revealed the gastroduodenal involvement. However, it is not clear whether or not gastroduodenal lesions are specific to BD and SU because comorbid Helicobacter pylori infections and/or drug induced mucosal injury can be the cause of such lesions.
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