| Theme |
Laterally spreading tumor (LST) -- Toward a new era |
| Title |
Clinicopathological findings and molecular alterations of colorectal laterally spreading tumors |
| Author |
Tamotsu Sugai |
Division of Molecular Diagnostic Pathology, Department of Pathology, School of Medicine, Iwate Medical University |
| Author |
Noriyuki Uesugi |
Division of Molecular Diagnostic Pathology, Department of Pathology, School of Medicine, Iwate Medical University |
| Author |
Ryo Sugimoto |
Division of Molecular Diagnostic Pathology, Department of Pathology, School of Medicine, Iwate Medical University |
| Author |
Hiro-o Yamano |
Division of Gastroenterology, Akita Red Cross Hospital |
| Author |
Ryou Takagi |
Division of Gastroenterology, Akita Red Cross Hospital |
| Author |
Toshimi Chiba |
Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University |
| Author |
Takayuki Matsumoto |
Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University |
| [ Summary ] |
In general, colorectal laterally spreading tumors (LST) are classified into the LST-G and LST-NG categories. Previous studies have shown that colorectal LSTs have distinct clinicopathological features and a high potential for malignancy. The aims of this study are to review clinicopathological features and molecular findings related to colorectal LSTs. There is a significant diff erence in tumor location and histological type between LST-Gs and LST-NGs. On the other hand, the frequency of submucosal cancer is high in the specific types of LSTs. Whereas there was a high frequency of ki-ras and APC mutations found in the LST-G types, distinct molecular features were not found in LST-NGs. 5q LOH was a common molecular feature in both LSTGs and LST-NGs. Molecular and clinicopathological findings suggest that LST-Gs and LST-NGs exhibit different aspects of colorectal tumorigenesis. |