| Theme |
Recent advance in diagnosis and management of hereditary colorectal cancer |
| Title |
Lynch syndrome -- Histology |
| Author |
Naohiko Akimoto |
Surgical and Molecular Pathology, Dokkyo Medical University / Department of Gastroenterology, and Departments of Pathology and Integrative Oncological Pathology, Nippon Medical School |
| Author |
Hiroyuki Mitomi |
Surgical and Molecular Pathology, Dokkyo Medical University |
| Author |
Takeshi Nishigami |
Departments of Pathology, Steel Memorial Hirohara Hospital |
| Author |
Makoto Nishii |
Department of General Medicine and Community Health Science, Sasayama Medical Center, Hyogo College of Medicine |
| Author |
Kazuo Tamura |
Department of Life Science, Faculty of Science and Engineering, Kinki University |
| Author |
Shigeki Tomita |
Surgical and Molecular Pathology, Dokkyo Medical University |
| Author |
Kazuhito Ichikawa |
Surgical and Molecular Pathology, Dokkyo Medical University |
| Author |
Zenya Naito |
Departments of Pathology and Integrative Oncological Pathology, Nippon Medical School |
| Author |
Choitsu Sakamoto |
Department of Gastroenterology, Nippon Medical School |
| Author |
Takahiro Fujimori |
Surgical and Molecular Pathology, Dokkyo Medical University |
| [ Summary ] |
Colorectal carcinomas (CRCs) in patients with Lynch syndrome are characterized by medullary growth, poorly differentiated histology, mucinous or signet ring differentiation, tumor infiltrating lymphocytes and Crohn's-like lymphocytic reactions. These features are also commonly accepted as being CRC associated with a high probability of microsatellite instability. Lynch syndrome is therefore defined as a patient harbored pathogenic germline mutation in one of the DNA mismatch repair genes. Recognition of these histological features may contribute to the detection of CRC derived from this significant hereditary disease in routine pathological practice. |