INTESTINE Vol.16 No.3(4-3)


特集名 クローン病のTherapeutic Strategy ─ mucosal healingは治療のゴールか
題名 クローン病治療戦略─どのような患者に用いるか (3) 顆粒球成分吸着除去療法
発刊年月 2012年 05月
著者 上小鶴 孝二 兵庫医科大学内科学下部消化管科
著者 松本 譽之 兵庫医科大学内科学下部消化管科
【 要旨 】 近年，抗TNF-α療法の出現によりそれまで栄養療法が治療主体であったCrohn's disease（以下，CD）の治療指針は大きく進化した．しかし，なお治療に難渋する症例も少なくない．顆粒球成分吸着除去療法（granulocyte／monocyte adsorption；GMA）は，既存治療で寛解導入と維持が困難な大腸に病変を有するCDに対して併用治療されており，抗TNF-α療法に抵抗性の患者でも効果が現われている．
Theme Therapeutic strategy for Crohn's disease -- Should mucosal healing be a final goal?
Title Clinical efficacy of granulocyte and monocyte adsorption (GMA) for Crohn's disease patients
Author Kouji Kamikozuru Division of Lower Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine
Author Takayuki Matsumoto Division of Lower Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine
[ Summary ] Recently, therapy for Crohn's disease (CD) has advanced. It has come to include anti tumor necrosis factor-alpha antibodies (biologics). However, we still require additional therapeutic strategies for our CD patient who are refractory to these treatments. In this report, we summarize the clinical efficacy of unique granulocyte and monocyte adsorption (GMA), which has recently been introduced as a therapeutic option for refractory colitis CD patients in Japan. GMA is expected to achieve both remission induction and maintenance through applying it alone or concomitant administration with other interventions, in 256 cluding biologics.
戻る