| Theme |
Intestinal mucosal immunology update for clinician |
| Title |
Dysbiosis of intestinal microbiota and pathogenic bacteria in development of inflammatory bowel diseases |
| Author |
Takuya Takahashi |
Basic Research II department, Yakult Central Institute for Microbiological Research |
| Author |
Koji Nomoto |
Basic Research II department, Yakult Central Institute for Microbiological Research |
| [ Summary ] |
An abundant quantity of data has suggested that intestinal microbiota play a key role in the initiation and maintenance of inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. In healthy individuals, healthy intestinal microbiota construct symbiotic relationships with the host by gaining immune tolerance. It has, however, been demonstrated that excessive immunological responses to abnormal microbiota (dysbiosis) and increases in pathogenic organisms result in the development of IBD. Further studies concerning intestinal microbiota and gut immunity may reveal procedures to regulate intestinal microbiota for prevention of the onset of IBD and／or suppression of development of symptoms. |