| Theme |
The newest approach to the small intestinal diseases |
| Title |
Enteroscopic diagnosis of small intestinal involvement in adenomatous polyposis patients |
| Author |
Takayuki Matsumoto |
Department of Medicine and Clinical Science, Graduate School of Medical Science, Kyushu University |
| Author |
Mitsuo Iida |
Department of Medicine and Clinical Science, Graduate School of Medical Science, Kyushu University |
| [ Summary ] |
We examined 16 patients with adenomatous polyposis (FAP) with oral DBE prior to colectomy and 29 FAP patients with IOE. A comparison was made of the incidence and endoscopic fi ndings of adenoma as observed using the two procedures. DBE detected adenomas in the small intestine in 10 out of 16 patients (63%) and IOE did so in 15 out of 29 patients (52%, p0.05). Adenomas occurred predominantly in the jejunum, with diminutive polyps configurations. In addition, DBE detected nonpolypoid adenoma in one patient, and nodular, broad based protrusions in 3 patients, IOE observation detected advanced lesions in one patient. Patients with adenomas in the small intestine had more severe duodenal adenomatosis than those without them（p0.002）. In cases where APC was analyzed, the prevalence of adenomas in the small intestine was higher in patients with a mutation in exon 15 than in those without any mutation in the exon. These fi ndings suggest that DBE is equal to IOE for scrutiny of adenomas in the small intestine of FAP patients. |