| Theme |
Metastasis in colorectal submucosal cancer of IIc origin |
| Title |
Molecular pathological analysis of colorectal cancer with submucosal invasion, especially, non-protruded colorectal cancer with lymph node involvement |
| Author |
Toshihiro Kusaka |
Digestive Disease Center, Kyoto Katsura Hospital |
| Author |
Masashi Yamakawa |
Digestive Disease Center, Kyoto Katsura Hospital |
| Author |
Ayao Torii |
Digestive Disease Center, Kyoto Katsura Hospital |
| Author |
Shigehiko Fujii |
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kyoto University, Postgraduate School of Medicine |
| Author |
Takahiro Fujimori |
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine |
| [ Summary ] |
In order to clalify the morphogenetic backgrounds of colorectal cancer with submucosal invasion, especially, non-protruded colorectal cancer with lymph node involvement, we histopathologically classified colorectal cancers into the non-protruded (NP) and protruded (P) type. The NP type was classified into two subtypes, intermediate (I) and typical NP. We analyzed the clinicopathological parameters and K-ras point mutations along with the immunoreactivities of p53 and adhesion molecules (β-catenin and E-cadherin) in colorectal cancer. Typical NP cancers showed a higher incidence of sm-massive invasion (depth > 1,000 μm) and tumor sprouting as well as lymph node involvement in comparison to P type cancers. In cases with lymph node involvement, the incidence of NP type cancer increased in comparison to those with no lymph node involvement. In cases with typical NP cancer, the menbranous immunoreactivities of adhesion molecules decreased in comparison to those with P type cancers and nuclear accumulations of p53 and β-catenin increased in comparison with P type cancers. These results suggest that most typical NP cancers may have greater invasive potential than P type cancers. |