| 特集名 | 肥満と消化器 | |
|---|---|---|
| 題名 | 肥満症の治療 (1) 食事・運動療法―メタボリック症候群の治療を目的とした肥満解消の食事療法・運動療法 | |
| 発刊年月 | 2019年 04月 | |
| 著者 | 山崎 聡 | 琉球大学大学院医学研究科内分泌代謝・血液・膠原病内科学講座（第二内科）／福島県立医科大学糖尿病内分泌代謝内科学講座 |
| 著者 | 尾形 絵美 | 琉球大学大学院医学研究科内分泌代謝・血液・膠原病内科学講座（第二内科）／福島県立医科大学糖尿病内分泌代謝内科学講座 |
| 著者 | 益崎 裕章 | 福島県立医科大学糖尿病内分泌代謝内科学講座 |
| 【 要旨 】 | 食事・運動療法は減量に有効であり，減量依存性に代謝が改善することから，肥満症治療の基本である．食事療法では，エネルギー制限食で，肥満症では現在体重から3％，高度肥満症では5～10％の体重減少を目標とする．食事の内容では，動物性脂肪の依存性が報告され，食事と脳内報酬系の制御メカニズムの解明が今後の食事療法のブレークスルーとなりうる．並んで，運動療法は，減量に有効であるだけでなく，肥満の質を改善する可能性をもつ．一般に加齢に伴い骨格筋は減少し，死亡率を増加させるため，サルコペニアの予防は重要な課題である．興味深いことに，骨格筋の内分泌的作用が解明され，体内で最大の内分泌臓器になりうる．さらには，運動が脳に作用する機序が解明されたことから，脳に効かせる運動療法が期待されている． | |
| Theme | Obesity and Digestive Organ | |
|---|---|---|
| Title | Diet Therapy and Exercise Therapy for Obesity‒related Diseases | |
| Author | Satoru Yamazaki | Second Department of Internal Medicine, Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology, Graduate School of Medicine, University of the Ryukyus / Department of Diabetes, Endocrinology and Metabolism, School of Medicine, Fukushima Medical |
| Author | Emi Ogata | Second Department of Internal Medicine, Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology, Graduate School of Medicine, University of the Ryukyus / Department of Diabetes, Endocrinology and Metabolism, School of Medicine, Fukushima Medical |
| Author | Hiroaki Masuzaki | Department of Diabetes, Endocrinology and Metabolism, School of Medicine, Fukushima Medical University |
| [ Summary ] | Diet therapy and exercise therapy are the basis of obesity treatment. Both therapies are effective for reducing body weight, and metabolism is improved depending on the amount of weight lost. In diet therapy, the goal for reducing weight is 3 % from the present body weight for obesity and 5-10 % for morbid obesity. In addition to the content of the meal, animal fat addiction has been reported; therefore, revealing the mechanism between the control of dietary behavior and the Brain‒Reward‒System could be a breakthrough in future diet therapy. Exercise therapy is effective for reducing weight and has the possibility to improve the quality of life of obese patients. Because skeletal muscle decreases with aging and leads to an increase in mortality rate, developing a strategy to prevent sarcopenia is important. Interestingly, the endocrine action of skeletal muscle has been elucidated in recent studies. That is, the skeletal muscle could be the largest endocrine organ. Furthermore, the mechanism of how exercise acts on the brain has been elucidated, and exercise therapy is greatly anticipated for its positive effect on the brain. |
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