| 特集名 | 肥満と消化器 | |
|---|---|---|
| 題名 | 肥満と全身性疾患 (1) 肥満と肥満症・メタボリックシンドローム | |
| 発刊年月 | 2019年 04月 | |
| 著者 | 宇野 健司 | 帝京大学医学部内科学講座内分泌代謝・糖尿病内科 |
| 【 要旨 】 | 飽食の現代社会では，摂取エネルギーの増加と運動不足を基盤として，体格指数（BMI）≥25 で示される身体状況をもつ肥満の割合は増加して久しい．そのなかで，肥満に起因あるいは関連した健康障害を合併し医学的に減量を必要とする肥満症（obesity disease）の患者を，適切に選別し治療介入する必要がある． 現在，肥満症の健康障害としては11の疾患・健康障害が挙げられ，そのうち耐糖能障害，脂質異常症，高血圧はとくに，メタボリックシンドロームの主兆候と捉えられている． こうした患者では，動脈硬化に基づく脳心血管イベントの発症リスクが高率であることから，基礎的研究での病態メカニズム解明と，日常診療での早期治療介入の両側面における役割が非常に重要である． |
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| Theme | Obesity and Digestive Organ | |
|---|---|---|
| Title | Obesity and Obesity Disease/Metabolic Syndrome | |
| Author | Kenji Uno | Division of Endocrine Metabolism and Diabetes, Department of Internal Medicine, Teikyo University School of Medicine |
| [ Summary ] | In the present age of satiation, lifestyle habits, such as excess calorie intake and lack of exercise, are common. According to the trend of our times, obesity, which is caused by the increase of body weight （BMI≥25）, is growing at a rapid rate. In particular, patients with obesity diseases need to reduce their body weight for medical reasons. It is important to treat patients with obesity diseases caused by their obesity. Furthermore, it is also necessary to subject them to medical intervention at an early stage. Currently, 11 health impairments are listed as the features associated with obesity diseases. Among these unhealthy conditions, glucose intolerance, hyperlipidemia, and hypertension are considered the main feature of metabolic syndrome. Patients with metabolic syndrome have a high risk of cardiovascular and cerebrovascular diseases, based upon atherosclerosis. Therefore, clarification of the physiological and pathophysiological mechanisms of obesity disease and metabolic syndrome through basic science is needed, and these patients provided with adequate therapy in clinical settings. |
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