| Theme |
Reconsideration of Gastritis |
| Title |
Changes of Gastric Mucosa after Helicobacter pylori Eradication |
| Author |
Masaaki Kodama |
Faculty of Welfare and Health Science, Oita University / Department of Gastroenterology, Faculty of Medicine, Oita University |
| Author |
Tadayoshi Okimoto |
Department of Gastroenterology, Faculty of Medicine, Oita University |
| Author |
Kazuhiro Mizukami |
Department of Gastroenterology, Faculty of Medicine, Oita University |
| Author |
Ryo Ogawa |
Department of Gastroenterology, Faculty of Medicine, Oita University |
| Author |
Kazuhisa Okamoto |
Department of Gastroenterology, Faculty of Medicine, Oita University |
| Author |
Kazunari Murakami |
Department of Gastroenterology, Faculty of Medicine, Oita University |
| [ Summary ] |
Helicobacter pylori eradication dramatically changes gastric mucosal findings. Atrophic gastritis and intestinal metaplasia are altered long term after successful eradication. Although several studies have reported changes in gastric atrophy and intestinal metaplasia after eradication, whether eradication improves atrophic gastritis and intestinal metaplasia remains unclear. Atrophic gastritis and intestinal metaplasia are recognized as precancerous lesions that can evolve into gastric cancer. Recent studies have reported a reduction in the risk of gastric cancer following H. pylori eradication; however, eradication does not completely suppress gastric carcinogenesis. Therefore, improvement in gastric atrophy and intestinal metaplasia after H. pylori eradication require close and careful observation to estimate the gastric cancer risk. Recent studies, including several meta‒analyses have reported that gastric mucosal atrophy improved in both the antrum and the corpus after H. pylori eradication; however, intestinal metaplasia remained comparatively irreversible. However, recent studies report conflicting results. Further large‒scale studies with longer follow‒up are warranted to gain a deeper understanding of the effect of H. pylori eradication on atrophic changes and intestinal metaplasia observed in the gastric mucosa. |