臨牀消化器内科 Vol.33 No.8(4)


特集名 大腸腫瘍治療後のサーベイランス
題名 早期大腸癌内視鏡摘除後のサーベイランス
発刊年月 2018年 07月
著者 南出 竜典 国立がん研究センター東病院消化管内視鏡科
著者 池松 弘朗 東京大学医学部附属病院肝胆膵外科
著者 新村 健介 東京大学医学部附属病院肝胆膵外科
著者 大野 康寬 東京大学医学部附属病院肝胆膵外科
著者 矢野 友規 東京大学医学部附属病院肝胆膵外科
【 要旨 】 大腸粘膜内癌(pTis癌)の内視鏡摘除後サーベイランスは,JPS(Japan Polyp Study)の結果に基づくと,2回のTCSの後,3年以上の間隔を空けてもよい.一方,リンパ節転移のリスクを有する粘膜下層浸潤癌(pT1癌)について,内視鏡摘除単独で長期経過観察を行った報告は少ない.今回,当院における186例を対象として,再発率・7年無病生存率・7年全生存率に関する遡及的検討を行った.経過観察期間中央値は約7年で,高リスク群のpT1癌には外科的追加切除が推奨され,高リスク群だけでなく直腸pT1癌は結腸pT1癌と比較して再発率が有意に高い結果となった.さらに,再発までの期間が5年を超えた症例がみられ,pT1癌内視鏡摘除後は5年以上の経過観察を要すると考えられた.
Theme Surveillance after Treatment for Colorectal Tumors
Title Surveillance after Endoscopic Resection for Early Colorectal Cancer
Author Tatsunori Minamide Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East
Author Hiroaki Ikematsu Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East
Author Kensuke Shinmura Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East
Author Yasuhiro Ono Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East
Author Tomonori Yano Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East
[ Summary ] After endoscopic resection for intramucosal colorectal cancer (Tis), an interval of over three years after double total colonoscopy is recommended as the optimal surveillance modality as determined by the JPS (Japan Polyp Study). On the other hand, there are few reports concerning long-term follow-up after endoscopic resection only for submucosal invasive colorectal cancer (pT1), which presents a risk for lymph node metastasis. We retrospectively analyzed one hundred eighty six patients with pT1 cancer having had endoscopic resection and assessed recurrence rates, seven year disease free survival, and seven year overall survival rates. After a median follow-up of about seven years, our results revealed that high risk pT1 cancer should be treated with additional surgery after endoscopic resection. Rectal pT1 cancers were at higher risk of recurrence than colonic pT1 cancers. Moreover, there were some cases which recurred more than five years after initial endoscopic resection. We have determind post endoscopic resection patients with pT1 cancers should receive follow ups for over five years.
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