臨牀消化器内科 Vol.33 No.6(3-1)


特集名 ガイドラインに基づいた肝癌診療
題名 肝癌治療の実際 (1) 肝切除術
発刊年月 2018年 06月
著者 久保 正二 大阪市立大学大学院肝胆膵外科学
著者 竹村 茂一 大阪市立大学大学院肝胆膵外科学
著者 田中 肖吾 大阪市立大学大学院肝胆膵外科学
著者 新川 寛二 大阪市立大学大学院肝胆膵外科学
【 要旨 】 肝細胞癌に対する肝切除術の適応と術式は腫瘍条件と肝機能予備力から決定される.腫瘍径に制限はないが,腫瘍数3個までが良い適応である.一次分枝までの門脈侵襲例は手術適応となる.切除断端距離は必要最低限でよい.術前肝機能予備力評価にはICG負荷試験が用いられる.間欠的肝流入血流遮断法や下大静脈圧低下によって肝切離中出血量が減少する.腹腔ドレーンは必ずしも必要としない.肝前下領域(segment2~6)に存在する単発5cm 以下の腫瘍に対する肝部分切除術や肝外側区域切除術が腹腔鏡下肝切除術の良い適応である.腹腔鏡下広範囲肝切除術では十分な腹腔鏡下肝切除術の経験と術前の難易度評価などを考慮することが必要である.
Theme The New Guideline for Liver Cancer Treatment
Title Liver Resection
Author Shoji Kubo Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine
Author Shigekazu Takemura Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine
Author Shogo Tanaka Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine
Author Hiroji Shinkawa Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine
[ Summary ] The indications and the extent of liver resection are determined based on the tumor stage and liver functional reserve. The presence of less than three tumors is a good indication for liver resection. When the liver function is adequate and curative resection is possible, surgery is indicated for tumors with vascular (portal and hepatic veins, and bile duct) invasion. To evaluate the liver function, the indocyanine green retention test is usually performed. Intermittently stopping the inflow to the liver and decreasing the central vein pressure can reduce the degree of bleeding during liver parenchymal dissection. The use of abdominal drainage is not routinely carried out for elective hepatic resection. A partial resection or lateral segmentectomy is indicated for solitary tumors measuring 5 cm or less in diameter, which are located in the antero-inferior area (segment 2-6) of the liver. Sufficient experience in performing laparoscopic procedures and accurate evaluation of the difficulty level associated with laparoscopic liver resection are necessary to perform extended laparoscopic liver resection safely.
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