臨牀消化器内科 Vol.33 No.1(1)


特集名 NASH 2018
題名 NASH・NAFLDの疫学
発刊年月 2018年 01月
著者 川口 巧 久留米大学医学部内科学講座消化器内科部門
著者 鳥村 拓司 久留米大学医学部内科学講座消化器内科部門
【 要旨 】 生活習慣の変化などにより,非アルコール性脂肪性肝疾患(NAFLD)の患者数は増加の一途を辿り,本邦におけるNAFLDの有病率は健診受診者の約30%となっている.NAFLDのおもな要因は過食であるが,非肥満者や小児のNAFLDでは偏食や車通学といった要因も重要である.また,一般人口におけるNAFLD有病率の上昇と同様に,NAFLD関連肝硬変や肝癌患者数も増加している.さらに,NAFLDはインスリン抵抗性や腸内環境と深く関わることから,糖尿病・循環器疾患・炎症性腸疾患患者において有病率が高い.本稿では,NAFLDの疫学について最近の知見を中心に概説する.
Theme NASH 2018
Title Epidemiology of NAFLD and NASH
Author Takumi Kawaguchi Division of Gastroenteorlogy, Department of Medicine, Kurume University School of Medicine
Author Takuji Torimura Division of Gastroenteorlogy, Department of Medicine, Kurume University School of Medicine
[ Summary ] The prevalence of nonalcoholic fatty liver disease (NAFLD) has been rapidly increasing. Currently, NAFLD is found in about 30 % of subjects who undergo an annual health check‒up in Japan. Although overeating is thought to be a main causative factor of NAFLD, other factors, including an unbalanced diet and travelling to school by car, are also risk factors for non‒obese NAFLD and NAFLD in children. In the general population, the prevalence of NAFLD is increasing among patients with liver cirrhosis and hepatocellular carcinoma. In addition, recent studies have shown that the prevalence of NAFLD is high in patients with type 2 diabetes mellitus, cardiovascular diseases, and inflammatory bowel disease. In this review, we describe the epidemiology of NAFLD by focusing on recent progress in the field studies or surveys.
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