| Theme |
Roles and Importance of Microbiota in Clinical Medicine |
| Title |
Effect of Probiotics on Gut Microbiota and Current Status of Their Clinical Application |
| Author |
Yoshikiyo Okada |
Department of Internal Medicine, National Defense Medical College |
| Author |
Ryota Hokari |
Department of Internal Medicine, National Defense Medical College |
| [ Summary ] |
Probiotics are currently defined as "live microorganisms or foods containing them, which when consumed in adequate amounts, confer a health effect on the host." So far, many species of microorganisms have been ascribed with probiotic properties, and studies into their functional mechanisms and clinical applications have been attempted. Results on probiotics efficacy in prevention and treatment of several conditions have been variable ; consequently, further research is needed to better establish probiotics efficacy. Analysis of the effect of probiotic administration on gut microbiota has recently advanced, thanks to next‒generation analytical methods such as metagenomic studies. The data obtained with these studies are expected to help elucidate the mechanism of action of probiotics and develop more effective clinical applications. |