| Theme |
Roles and Importance of Microbiota in Clinical Medicine |
| Title |
Gut Microbiota and NSAID‒induced Small Intestinal Ulcer |
| Author |
Takayuki Kato |
Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine |
| Author |
Takaomi Kessoku |
Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine |
| Author |
Takuma Higurashi |
Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine |
| Author |
Atsushi Nakajima |
Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine |
| [ Summary ] |
The mechanism underlying nonsteroidal anti‒inflammatory drug (NSAID)‒induced small intestinal mucosal injury is yet to be fully understood. However, among the several factors considered to be involved, gut microbiota composition is definitely a key factor according to the results of various studies. In addition, proton pump inhibitor (PPI), which is widely known and used to prevent upper gastrointestinal (GI) disorders caused by NSAID, has been recently related to NSAID‒induced small intestinal disorders by causing dysbiosis of the gut microbiota. Further studies are needed in order to identify an effective treatment for NSAID‒related small intestinal disorders and resolve the paradoxical effect caused by the concomitant use of NSAID and PPI. |