| [ Summary ] |
Recent studies on innate immunity have evidenced a role for intestinal bacteria in intestinal inflammation. In addition, inflammatory bowel disease (IBD) has been recognized as an intestinal bacterial infection. Recently developed methods for analyzing bacterial DNA have been used to try to identify the causative bacteria, or bacterial groups, of IBD within the great variety of intestinal bacteria. In the metagenomic analysis of 16S rRNA and DNA, have shown that there is dysbiosis in IBD with an increase in abundance of bacteria of the phylum Firmicutes, such as Lactobacillus, Faecalibacterium prausnitzii, and Roseburia hominis ; the phylum Actinobacteria ; the phylum Proteobacteria, such as Enterobacteriaceae and sulfate‒reducing bacteria ; and the phylum Bacteroidetes, such as Bacteroides. Since this dysbiosis is commonly observed in association with high‒fat diets (animal and vegetable) and high red meat consumption (which results in high levels of iron), dietary guidance such as fat and red meat restriction may be helpful for treatment of IBD. |