臨牀消化器内科 Vol.31 No.9(3-1)


特集名 臨床に必要な消化管による食欲調節の知識
題名 腸内細菌と食欲 (1) H.pylori感染と食欲
発刊年月 2016年 08月
著者 楠 裕明 川崎医科大学総合臨床医学
著者 山下 直人 川崎医科大学総合臨床医学
著者 本多 啓介 川崎医科大学総合臨床医学
著者 鎌田 智有 川崎医科大学消化管内科学
著者 塩谷 昭子 川崎医科大学消化管内科学
著者 春間 賢 川崎医科大学附属川崎病院総合内科学2
【 要旨 】 食欲は体の恒常性を維持するための非常に重要な機能であり,消化管局所の運動や分泌だけでなく,中枢性および末梢性の因子や門脈内グルコース濃度によっても調節を受ける.末梢性の食欲調節因子では短期的なものにグレリンがあり,長期的なものにレプチンが存在する.H. pyloriは消化管機能と無関係とされてきたが,除菌治療後に食欲が亢進することなどから研究が進み,現在は機能性ディスペプシアの原因の一つとして扱われるようになったが,それらの現象にはいずれもグレリンとレプチンが関与している.本項ではH. pylori感染や除菌治療がFD症状や食欲に与える影響ついて,グレリンとレプチンを中心に述べる.
Theme The Gastrointestinal Tract and Appetite Control : Essential Clinical Knowledge
Title Helicobacter pylori Infection and Appetite
Author Hiroaki Kusunoki Department of General Medicine, Department of Internal Medicine, Kawasaki Medical School
Author Naohito Yamashita Department of General Medicine, Department of Internal Medicine, Kawasaki Medical School
Author Keisuke Honda Department of General Medicine, Department of Internal Medicine, Kawasaki Medical School
Author Tomoari Kamada Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School
Author Akiko Shiotani Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School
Author Ken Haruma Department of General Medicine 2, Kawasaki Medical Hospital
[ Summary ] Appetite plays a very important role in maintaining the homeostasis of the body. Appetite is controlled by the neuroendocrine system, consisting of complex central and peripheral factors. Glucose concentration in the portal vein also controls appetite, as well as gastrointestinal motility and secretion. With respect to peripheral factors regulating appetite, ghrelin affects appetite in the short‒term, and leptin in the long‒term. Although it was previously thought that Helicobacter pylori infection had no effect on the function of the digestive tract, this microorganism has recently been found to be a cause of functional dyspepsia. It has also been established that appetite is enhanced after eradication therapy for Helicobacter pylori, and that both ghrelin and leptin are involved in the mechanisms underlying this phenomenon. In this report, we use theories involving ghrelin and leptin, in particular when describing the mechanism by which Helicobacter pylori infection induces FD symptoms, and the pathogenesis by which the eradication therapy improves FD symptoms and appetite.
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