臨牀消化器内科 Vol.31 No.5(9)


特集名 急性膵炎―診療ガイドラインの改訂を受けて
題名 胆石性膵炎
発刊年月 2016年 05月
著者 桐山 勢生 大垣市民病院消化器内科
著者 熊田 卓 大垣市民病院消化器内科
著者 谷川 誠 大垣市民病院消化器内科
著者 久永 康宏 大垣市民病院消化器内科
著者 豊田 秀則 大垣市民病院消化器内科
著者 金森 明 大垣市民病院消化器内科
著者 多田 俊史 大垣市民病院消化器内科
著者 北畠 秀介 大垣市民病院消化器内科
著者 山 剛基 大垣市民病院消化器内科
【 要旨 】 胆石性膵炎は,他の膵炎と同様に膵炎を主体とする症例から重症胆管炎を併発した症例まで多様な病態を示す.急性膵炎の診断後ただちに成因検索を行い胆石性か否かを判断する.血液検査で肝胆道系酵素の上昇を認め,画像で胆管結石が証明されれば胆石性と判断されるが,小結石やpassed stoneの症例も少なくなく,膵炎急性期には胆管結石が描出できないこともあり胆囊結石や胆石の手術歴などの間接的な所見から総合的に判断する.治療は,他の膵炎と同様に膵炎に対する基本的な保存的治療を行う.通常は膵炎鎮静後にERCPを行って胆管結石を確認して内視鏡的に治療するが,胆管炎や胆道通過障害があれば膵炎急性期にも緊急ERCP/ESを行うことが推奨されている.
Theme Management of Acute Pancreatitis Based on the Revised JPN Guidelines
Title Acute Biliary Pancreatitis
Author Seiki Kiriyama Department of Gastroenterology, Ogaki Municipal Hospital
Author Takashi Kumada Department of Gastroenterology, Ogaki Municipal Hospital
Author Makoto Tanikawa Department of Gastroenterology, Ogaki Municipal Hospital
Author Yasuhiro Hisanaga Department of Gastroenterology, Ogaki Municipal Hospital
Author Hidenori Toyota Department of Gastroenterology, Ogaki Municipal Hospital
Author Akira Kanamori Department of Gastroenterology, Ogaki Municipal Hospital
Author Toshifumi Tada Department of Gastroenterology, Ogaki Municipal Hospital
Author Syusuke Kitabatake Department of Gastroenterology, Ogaki Municipal Hospital
Author Tsuyoki Yama Department of Gastroenterology, Ogaki Municipal Hospital
[ Summary ] Gallstones are the commonest causes of acute pancreatitis. The clinical practice guidelines present the following management strategy for acute biliary pancreatitis. After the diagnosis of acute pancreatitis, its etiology should be classified as biliary or non‒biliary based on laboratory and imaging investigations. However, diagnosing choledocholithiasis using imaging studies is often difficult, because in many patients with acute biliary pancreatitis, the gallstones are either small or have passed through the ampulla of Vater. Similar to other types of pancreatitis, the initial treatment of biliary pancreatitis is usually conservative, and includes bowel rest, intravenous replacement of fluids and electrolytes, and analgesia. Additionally, treatment of associated biliary tract disease is necessary. Furthermore, it is important to adequately plan the timing of intervention for clearance of gallstones. From reviews of clinical trials and meta‒analyses, the practice guidelines recommend urgent endoscopic retrograde cholangiopancreatography and sphincterotomy (ERCP/ES) only in cases of cholangitis or persistent biliary obstruction. In order to reduce the risk of recurrent acute pancreatitis or other biliary complications, cholecystectomy should be performed after pancreatitis has subsided, if the perioperative risk of the patient is reasonable.
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