臨牀消化器内科 Vol.31 No.12(2-4)


特集名 大腸内視鏡のリスクマネジメント
題名 各論 (4) ポリペクトミー,EMR,ESDにおけるリスクマネジメント
発刊年月 2016年 11月
著者 樫田 博史 近畿大学医学部消化器内科
著者 米田 頼晃 近畿大学医学部消化器内科
著者 櫻井 俊治 近畿大学医学部消化器内科
著者 朝隈 豊 近畿大学医学部消化器内科
著者 峯 宏昌 近畿大学医学部消化器内科
著者 足立 哲平 近畿大学医学部消化器内科
【 要旨 】 大腸腫瘍の内視鏡治療における代表的な偶発症は,出血と穿孔であり,それぞれ術中と術後に区別される.後出血は,顕性血便,2g/dl以上のヘモグロビン低下,輸血や止血処置を要したものと定義される.抗血栓薬の扱いは基本的にガイドラインに従う.術中出血予防には高周波装置の適切な設定が必要である.有茎性ポリープにおいて,留置スネアは術中出血・後出血の予防になる.EMRでは筋層を巻き込むと,ESDでは筋層の方向に通電してしまうと術中穿孔をきたす.下部直腸,上行・下行結腸背面など漿膜のない部位では,筋層を貫通した時点で即,穿孔である.小さい病変では,コールドポリペクトミーのほうが,後出血や穿孔のリスクが低い.EMRやESD後のクリップによる創閉鎖は,大型病変や抗血栓療法下以外では後出血予防効果は期待できないが,遅発性穿孔予防には有効であると思われる.
Theme Risk Management in Colonoscopy
Title Risk Management in Polypectomy, EMR and ESD
Author Hiroshi Kashida Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine
Author Yoriaki Komeda Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine
Author Toshiharu Sakurai Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine
Author Yutaka Asakuma Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine
Author Hiromasa Mine Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine
Author Teppei Adachi Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine
[ Summary ] Complications associated with endoscopic treatments for colorectal neoplasia include bleeding and perforation, each of which is categorized as onsite or delayed. Delayed bleeding is defined as overt bleeding that is associated with a ≥2 g/dl decrease in hemoglobin, or that requires blood transfusion or endoscopic hemostasis. In patients receiving antithrombotic therapy, the guidelines published by medical societies should be referred to. In a pedunculated polyp, an endoloop can prevent onsite and delayed bleeding. Onsite perforation may occur when the muscle layer is involved within the snare during endoscopic mucosal resection (EMR), or when the electrical spark is directed to the muscle layer during endoscopic submucosal dissection (ESD). In the lower rectum or in the posterior wall of the ascending or descending colon, injury to the muscle layer directly leads to perforation, as such areas are not covered by a serosal membrane. Cold polypectomy is considered to be associated with lower risk of perforation and delayed bleeding in cases with small polyps. Closure with clips will not prevent delayed bleeding in mucosal defects after EMR or ESD, except in patients with large lesions or those receiving anti?thrombotic therapy, but should be effective for preventing delayed perforation in high?risk conditions.
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