| Theme |
Unraveling of the Pathophysiology of Functional Gastrointestinal Disorders and Updated Treatments |
| Title |
Pathophysiology of Functional Gastrointestinal Diseases -- Gastrointestinal Motility Dysfunction and Susceptibility in Patients with Irritable Bowel Syndrome |
| Author |
Noriaki Manabe |
Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School |
| Author |
Hiroaki Kusunoki |
Department of Health Care Medicine, Kawasaki Medical School |
| Author |
Tomoari Kamada |
Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School |
| Author |
Kazuhiko Inoue |
Department of Health Care Medicine, Kawasaki Medical School |
| Author |
Jiro Hata |
Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School |
| Author |
Ken Haruma |
Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School |
| [ Summary ] |
Gastrointestinal motility dysfunction, visceral hypersensitivity, and psychosocial stress are considered important basic factors that are involved in the pathophysiology of irritable bowel syndrome (IBS), but do not sufficiently explain IBS symptoms. New areas of research, including altered microbiota, dietary factors, genetic factors, and inflammation, are currently in progress, which may lead to the development of a more specific, individualized treatment strategy for IBS patients in the near future. |