臨牀消化器内科 Vol.30 No.13(2-3)


特集名 カプセル内視鏡の現況と最新動向
題名 カプセル内視鏡の意義と役割 (3) 炎症性腸疾患(クローン病を除く)の小腸病変の検討
発刊年月 2015年 12月
著者 岡本 康治 九州大学大学院病態機能内科学/九州大学先端医療イノベーションセンター
著者 森山 智彦 九州大学大学院病態機能内科学
著者 原田 英 松山赤十字病院胃腸センター
著者 河内 修司 九州大学大学院病態機能内科学
著者 蔵原 晃一 松山赤十字病院胃腸センター
著者 江﨑 幹宏 九州大学大学院病態機能内科学
【 要旨 】 腸管ベーチェット病(BD)とNSAIDs起因性小腸粘膜傷害のカプセル内視鏡(CE)所見を比較した.いずれも,空腸および回腸に粘膜病変が多発していたが,腸管BDでは空腸病変は少なく,回腸を中心に病変が出現していた.潰瘍の形態に着目すると,いずれの疾患でも不整形潰瘍を呈する例が多く,腸管BDに特徴的な類円形の打ち抜き様潰瘍を認めたのは3例で出現率は高くなかった.なお,CE施行時に消化器症状を伴わなかった1例で後に小腸穿孔をきたし腸管切除術を要した.腸管BDの鑑別疾患としてNSAIDs起因性小腸粘膜傷害が挙げられるが,病変の分布や形態に着目すれば両疾患はある程度鑑別しうると思われた.また,腸管BDでは無症状でも小腸病変を伴う場合が多く,CEによる小腸病変の評価が望ましいと思われた.
Theme Capsule Endoscopy -- Current States and the Latest Developments
Title Capsule Endoscopic Findings of the Small Intestine in Patients with Behçet's Disease
Author Yasuharu Okamoto Department of Medicine and Clinical Science, Graduate School of Medical Sciences / Center for Advanced Medical Innovation, Kyushu University
Author Tomohiko Moriyama Department of Medicine and Clinical Science, Graduate School of Medical Sciences
Author Akira Harada Division of Gastroenterology, Matsuyama Red Cross Hospital
Author Shuji Kochi Department of Medicine and Clinical Science, Graduate School of Medical Sciences
Author Koichi Kurahara Division of Gastroenterology, Matsuyama Red Cross Hospital
Author Motohiro Esaki Department of Medicine and Clinical Science, Graduate School of Medical Sciences
[ Summary ] We compared capsule endoscopic findings of the small intestine between patients with Behçet's disease (BD) and those with NSAIDs induced enteropathy. Small intestinal mucosal injury was observed in 92 % of BD patients. Although most patients with BD manifested no gastrointestinal symptoms, the prevalence of ulcer was higher in BD than in NSAIDs induced enteropathy. Small intestinal lesions of BD were multiple and were predominantly seen in the ileum when compared to those of NSAIDs induced enteropathy. Oval discrete ulcer, which is thought to be a characteristic endoscopic finding of BD, was not frequent in the small intestine. In one patient with BD, ileal perforation requiring emergency surgery occurred during the follow‒up period. Although obvious differences were not observed in CE findings between BD and NSAIDs induced enteropathy, CE seems useful to some extent in the diagnosis and management of BD.
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