臨牀消化器内科 Vol.30 No.12(4-1)


特集名 LECS(laparoscopy and endoscopy cooperative surgery)の新たな展開
題名 胃以外への応用 (1) 十二指腸におけるLECS
発刊年月 2015年 11月
著者 港 洋平 NTT東日本関東病院消化器内科
著者 大圃 研 NTT東日本関東病院消化器内科
著者 野中 康一 NTT東日本関東病院消化器内科
著者 松橋 信行 NTT東日本関東病院消化器内科
著者 山崎 公靖 昭和大学医学部消化器・一般外科
著者 村上 雅彦 昭和大学医学部消化器・一般外科
【 要旨 】 表在性非乳頭部十二指腸腫瘍における治療法は内視鏡治療は技術的に困難であり穿孔や後出血のリスクが高く,胆汁・膵液曝露による合併症などの解決すべき問題を抱えており,とくに遅発性穿孔は致死的になることもある.一方,外科切除は侵襲的で,腫瘍部位の同定や局所切除が部位によっては難しく,治療法が確立されていない.われわれはこれらの問題点を解決すべく,内視鏡補助下腹腔鏡下十二指腸全層切除術(endoscopy‒assisted laparoscopic full‒thickness resection;EALFTR)を考案した.これまで蓄積した症例をもとに,今回,その治療対象,手術概要,治療成績について概説した.まだまだ問題点もあるが十二指腸LECSの今後の可能性に期待する.
Theme New Developments in Laparoscopy and Endoscopy Cooperative Surgery (LECS)
Title Endoscopy—assisted Laparoscopic Full—thickness Resection of Superficial Duodenal Neoplasms
Author Yohei Minato Gastroenterology, NTT Medical Center Tokyo
Author Ken Ohata Gastroenterology, NTT Medical Center Tokyo
Author Kouichi Nonaka Gastroenterology, NTT Medical Center Tokyo
Author Nobuyuki Matsuhashi Gastroenterology, NTT Medical Center Tokyo
Author Kimiyasu Yamazaki Gastroenterological and General Surgery, Showa University Hospital
Author Masahiko Murakami Gastroenterological and General Surgery, Showa University Hospital
[ Summary ] Superficial non‒ampullary duodenal tumors (SNADTs) are a challenging target in the digestive tract. Endoscopic resection has scarcely been utilized in the treatment of duodenal tumors because of technical difficulties and possible delayed perforation due to the action of digestive juices. On the other hand, surgical resection is an invasive method, in which determining the borderline of the lesion from outside the intestine and resecting it locally are difficult. Thus, no standard treatments of SNADT have been established. To overcome these problems, we invented a new approach for the removal of SNADTs, called "endoscopy‒assisted laparoscopic full‒thickness resection (EALFTR)", that involves a combination of endoscopic and laparoscopic techniques. Between January 2011 and March 2015, we treated 85 patients with 90 SNADTs. Successful en bloc R0 resection and full‒thickness excision were achieved with an adequate surgical margin in all of the patients without severe complications. The outcome indicates that EALFTR can be a feasible, safe, and minimally invasive treatment option for SNADTs. However, many problems remain to be solved (adaptation, peritoneal exposure, and complicated procedure). We expect more improvements in the development of duodenum laparoscopy‒endoscopy cooperative surgery.
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